Can moderation be applied to individual posts or ads?

No. CommentGuard applies moderation settings at the page level, not to individual posts or ads. You can't auto-hide comments on only specific posts or ads.

You also can't use different settings for organic posts vs ads. You can choose to apply that one set of rules to ads, organic posts, or both.

See Can I enable CommentGuard only on ads and not on organic posts?